Urinary Excretion of Androgenic Substances after Intramuscular and Oral Administration of Testosterone Propionate to Humans.

The urinary excretion of estrogens following administration of female sex hormones has been compared with the relief obtained from hot flushes and other phenomena accompanying the menopause (1) and has been studied with regard to the percentage of the administered material which appears in the urine (3 to 12 per cent) (2). Studies of the excretion of urinary androgens following the treatment of patients with testosterone propionate are reported below with regard to (a) the rapidity of the appearance and comparative levels of excretion in oral and intramuscular treatment, (b) the percentage of recovery in the urine of admninistered material, and (c) the evaluation of urinary levels of androgens as criteria of effective levels of male hormone in the body.